Eosinophils by Targetting the Common Cytokine Binding Site of Their Colony-Stimulating Factor, and Interleukin-3 Stimulation of Human Simultaneous Antagonism of Interleukin-5, Granulocyte-Macrophage
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منابع مشابه
Simultaneous antagonism of interleukin-5, granulocyte-macrophage colony-stimulating factor, and interleukin-3 stimulation of human eosinophils by targetting the common cytokine binding site of their receptors.
Human interleukin-5 (IL-5), granulocyte-macrophage colony-stimulating factor (GM-CSF), and IL-3 are eosinophilopoietic cytokines implicated in allergy in general and in the inflammation of the airways specifically as seen in asthma. All 3 cytokines function through cell surface receptors that comprise a ligand-specific alpha chain and a shared subunit (beta(c)). Although binding of IL-5, GM-CSF...
متن کاملGranulocyte-Macrophage Colony-Stimulating Factor, Interleukin-3 (IL-3), and IL-5 Greatly Enhance the Interaction of Human Eosinophils With Opsonized Particles by Changing the Affinity
Eosinophil functions can be modulated by several cytokines such as granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin-3 (IL-31, and IL-5. We have investigated the modulatory role of these cytokines on the interaction of human eosinophils with opsonized particles (serumtreated zymosan [STZ]). Addition of ST2 to eosinophils isolated from the peripheral blood of normal human do...
متن کاملThe Human Granulocyte - Macrophage Colony - Stimulating Factor ( GM - CSF ) Receptor Exists as a Preformed Receptor Complex That Can Be Activated
The granulocyte-macrophage colony-stimulating factor GM-CSF. The preformed complex required only the extracellular regions of GMRa and bc , as shown by the ability of (GM-CSF) receptor is expressed on normal and malignant hematopoietic cells as well as on cells from other organs soluble bc to associate with membrane-anchored GMRa or soluble GMRa. Kinetic experiments on eosinophils and in which ...
متن کاملCooperative effects of interleukin-3 (IL-3), IL-5, and granulocyte-macrophage colony-stimulating factor: a new myeloid cell line inducible to eosinophils.
The cytokines interleukin-3 (IL-3); IL-5, and granulocyte-macrophage colony-stimulating factor (GM-CSF) are known to contribute to the proliferation and differentiation of eosinophil progenitors. Recently, it was determined that the cellular receptors for these three cytokines share a common beta-chain while having unique alpha-chains. Thus, there is considerable interest in how these cytokines...
متن کاملHuman eosinophils constitutively express a functional interleukin-4 receptor: interleukin-4 -induced priming of chemotactic responses and induction of PI-3 kinase activity.
Similar to interleukin-3 (IL-3), IL-5, and granulocyte macrophage colony-stimulating factor (GM-CSF), IL-4 can be secreted by several cell types involved in allergic inflammatory reactions, and therefore can affect eosinophil function similarly. In this study, we investigated the presence of an IL-4 receptor (IL-4R) on human eosinophils. When two different monoclonal antibodies (mAbs) against t...
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تاریخ انتشار 1999